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KMID : 0869620220390030288
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Journal of Korean Society of Hospital Pharmacists
2022 Volume.39 No. 3 p.288 ~ p.311
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Association Between Antidepressant Use and the Risk of Hospitalization for Pneumonia
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Choi Ha-Ram
Kim Hyeong-Rae
Yoo Si-Yeon
Shon Je-Yeong
Kim Jae-Song
Son Eun-Sun
Yu Yun-Mi
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Abstract
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Background : Pneumonia is one of the acute respiratory diseases leading to death in the elderly population, and the death rate from pneumonia is gradually increasing. However, there are not enough studies analyzing the impact of antidepressant use on the occurrence of pneumonia so far. Thus, the purpose of this study was to analyze if the use of antidepressants impacts hospitalization from pneumonia in patients older than 50.
Methods : This is a retrospective, case-control study of patients older than 50 admitted to Severance Hospital January 2018-December 2019. Afterwards, patients diagnosed with pneumonia were used as a case group and patients who were not diagnosed with pneumonia were used as a control group. The final target patient was selected by propensity score matching. Based on the index date of each patient, the recency, components, dose, and duration of antidepressant prescription for the previous a year were investigated.
Results : The use of antidepressants significantly increased the risk of hospitalization for pneumonia (model 3: adjusted OR [aOR] 1.69, 95% CI 1.31-2.17). As a result of analysis by class of antidepressants, except for model 1, taking atypical antidepressant significantly increased the risk of hospitalization from pneumonia (model 2: aOR 1.55, 95% CI 1.01-2.39; model 3: aOR 1.56, 95% CI 1.31-2.17). Also, in all models, the group taking TCA significantly increased the risk of hospitalization for pneumonia (model 3: aOR 1.68, 95% CI 1.02-2.79).
Conclusion : The use of antidepressants significantly increased the risk of hospitalization for pneumonia. The longer and more recent antidepressant use, the higher the risk of hospitalization for pneumonia. However, considering the limitations of this study, a long-term and prospective study is needed.
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KEYWORD
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Antidepressants, Pneumonia, Drug burden index
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